Skip to main content
Article thumbnail
Location of Repository

Afferent Connections to the Rostrolateral Part of the Periaqueductal Gray: A Critical Region Influencing the Motivation Drive to Hunt and Forage

By Sandra Regina Mota-Ortiz, Marcia Harumi Sukikara, Luciano Freitas Felicio and Newton Sabino Canteras


Previous studies have shown that a particular site in the periaqueductal gray (PAG), the rostrolateral PAG, influences the motivation drive to forage or hunt. To have a deeper understanding on the putative paths involved in the decision-making process between foraging, hunting, and other behavioral responses, in the present investigation, we carried out a systematic analysis of the neural inputs to the rostrolateral PAG (rlPAG), using Fluorogold as a retrograde tracer. According to the present findings, the rlPAG appears to be importantly driven by medial prefrontal cortical areas involved in controlling attention-related and decision-making processes. Moreover, the rlPAG also receives a wealth of information from different amygdalar, hypothalamic, and brainstem sites related to feeding, drinking, or hunting behavioral responses. Therefore, this unique combination of afferent connections puts the rlPAG in a privileged position to influence the motivation drive to choose whether hunting and foraging would be the most appropriate adaptive responses

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2000). A .K a s ka n dH .B .S c h i ¨ oth, “Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat,”
  2. (2006). A role for the periaqueductal gray in switching adaptive behavioral responses,”
  3. (1990). Animal models for human PFC-related disorders,”
  4. (2004). Axonal projections from the parasubthalamic nucleus,”
  5. (2008). Cez´ a r i o ,E .R .R i b e i r o - B a r b o s a ,M .V .C .B a l d o ,a n d
  6. (1998). Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area,”
  7. (2005). Comparison of melanin-concentrating hormone and hypocretin/orexin mRNA expression patterns in a new parceling schemeofthelateralhypothalamiczone,”
  8. (1991). Connections between the central nucleus of the amygdale and the midbrain periaqueductal gray: topography and reciprocity,”
  9. (1999). Connections of the precommissural nucleus,”
  10. (2007). Connectivity pattern suggests that incerto-hypothalamic area belongs to the medialhypothalamicsystem,”Neuroscience,vol.148,no.4,pp. 949–969,
  11. (1996). Descending projections of the posterior nucleus of the hypothalamus: Phaseolus vulgaris leucoagglutininanalysisintherat,”TheJournalofComparative Neurology,
  12. (2004). Differential projections of the infralimbic and prelimbic cortex in the rat,”
  13. (1999). Distinct patterns of neuropeptide gene expression in the lateral hypothalamic area and arcuate nucleus are associated with dehydration-induced anorexia,”
  14. (2002). Distribution of melanin-concentrating hormone neurons projecting to the medial mammillary nucleus,”
  15. (1991). Does the PAG learn about emergencies from the superior colliculus?” in The Midbrain Periaqueductal Gray Matter: Functional, Anatomical, and Neurochemical Organization,A .D e p a u l i sa n dR .B a n d l e r ,E d s . ,p p .
  16. (1998). Double dissociation of the behavioral effects of R(+) 7-OH-DPAT infusions in the central and basolateral amigdala nuclei upon Pavlovian and instrumental conditioned appetitive behaviors,”
  17. (1991). Efferent projections of the infralimbic (area 25) region of the medial prefrontal cortex in the rat: an anterograde tracer
  18. (2000). F l o y d ,J .L .P r i c e ,A .T .F e r r y ,K .A .K e a y ,a n d R. Bandler, “Orbitomedial prefrontal cortical projections to distinctlongitudinalcolumnsoftheperiaqueductalgrayinthe rat,”
  19. (1999). Fos-like immunoreactivity in the periaqueductal gray of rats exposed to a natural predator,”
  20. (1981). Frontal cortical projections to the periaquaductal gray in the rat: a retrograde and orthograde horseradish peroxidase study,”
  21. (1987). H a r l a n ,B .D .S h i v e r s ,G .J .R o m a n o ,D .W .P f a ff,a n dR
  22. (1991). H u r l e y ,H .H e r b e r t ,M .M .M o g a ,a n dC .B .S a p e r , “Efferent projections of the infralimbic cortex of the rat,”
  23. (2000). Lateralmost region of intermediate layer of superior colliculus: a critical site involved in the motor control of predatory hunting,”
  24. (2003). M i r a n d a - P a i v a ,E .R .R i b e i r o - B a r b o s a ,N .S .C a n t e r a s
  25. (1991). Midbrain periaqueductal gray control of defensive behavior in the cat and the rat,” in The Midbrain Periaqueductal Gray Matter: Functional,
  26. (1992). N.S.CanterasandL.W.Swanson,“Thedorsalpremammillary nucleus: an unusual component of the mammillary body,”
  27. (2000). Naltrexone administered to central nucleus of amygdala or PVN: neural dissociation of diet and energy,”
  28. (2005). Neural activation during cat odor-induced conditioned fear and “trial 2” fear
  29. (2003). o m o l i ,E .R .R i b e i r o - B a r b o s a ,a n dN .S .C a n t e r a s ,“ P r e d a -tory hunting and exposure to a live predator induce opposite patterns of Fos immunoreactivity in the PAG,”
  30. (2005). o m o l i ,E .R .R i b e i r o - B a r b o s a ,N .N e g r
  31. (2004). o n ga n dL .W .S w a n s o n ,“ P r o j e c t i o n sf r o mb e dn u c l e i of the stria terminalis, posterior division: implications for cerebral hemisphere regulation of defensive and reproductive
  32. (2007). Opiate regulation of behavioral selection during lactation,”
  33. (1994). Organization of projections from the anterior hypothalamic nucleus: a Phaseolus vulgaris-leucoagglutinin study in the rat,”
  34. (1996). Organization of projections from the basomedial nucleus of the amygdala: a PHAL study in the rat,”
  35. (1994). Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat,”
  36. (2000). P o m o n i s ,D .C .J e w e t t ,C .M .K o t z ,J .E .B r i g g s
  37. (1998). Periaqueductal gray matter projection to the parabrachial nucleus in rat,”
  38. (2005). Projections from the subfornical region of the lateral hypothalamic area,”
  39. (1999). Projections of the basal retrochiasmatic area: a neural site involved in the photic control of pineal metabolism,”
  40. (1986). Projections to the midbrain from the medial versus lateral prefrontal cortices of the rat,”
  41. (1981). Protein A, avidin, and biotin in immunohistochemistry,”
  42. (1991). Regional subdivisions in the midbrain periaqueductal gray of the cat revealed by in vitro receptor autoradiography,” in The Midbrain Periaqueductal Gray Matter: Functional,
  43. (1991). Retinohypothalamic tract in the female albino rat: a study usinghorseradishperoxidaseconjugatedtocholeratoxin,”The
  44. (1992). Sancibri´ a n ,P .S a l i n a s , a n dR
  45. (2003). Structural characterization of a hypothalamic visceromotor pattern generator network,”
  46. (1997). Study of the origins of melanin-concentrating hormone and neuropeptide EI immunoreactive projections to the periaquaductal gray matter,”
  47. (1983). The laminar distribution of intracortical fibers originating in the olfactory c´ ortex of the rat,”
  48. (1992). The melaninconcentrating hormone system of the rat brain: an immunoand hybridization histochemical characterization,”
  49. The organization of afferent projections to the midbrain periaqueductal gray of the rat,”
  50. (1993). The organization of the efferent projections from the pontine parabrachial area to the amygdaloid complex: a Phaseolus vulgaris leucoagglutinin (PHA-L) study in the rat,”
  51. (1993). The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold,” TheJournal ofComparativeNeurology,vol.338,no.2,pp.255– 278,
  52. (1989). The Prefrontal Cortex. Anatomy, Physiology and Neuropsychology of the Frontal Lobe,
  53. (1986). The topographical organization of neurons in the rat medial frontal, insular and olfactory cortex projecting to the solitary nucleus, olfactory bulb, periaqueductal gray and superior colliculus,”
  54. (1984). The topography of the mesencephalic and pontine projections from the cingulate cortex of the rat,”
  55. (1989). Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin,”10
  56. (1991). Topographical specificity of forebrain inputs to the midbrain periaqueductal gray: evidence for discrete longitudinally organized input columns,”

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.