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Noninvasive Quantification of Human Nucleus Pulposus Pressure with Use of T1ρ-Weighted Magnetic Resonance Imaging

By An M. Nguyen, Wade Johannessen, Jonathon H. Yoder, Andrew J. Wheaton, Edward J. Vresilovic, Arijitt Borthakur and Dawn M. Elliott


Background: Early diagnosis is a challenge in the treatment of degenerative disc disease. A noninvasive biomarker detecting functional mechanics of the disc is needed. T1ρ-weighted imaging, a spin-lock magnetic resonance imaging technique, has shown promise for meeting this need in in vivo studies demonstrating the clinical feasibility of evaluating both intervertebral discs and articular cartilage. The objectives of the present study were (1) to quantitatively determine the relationship between T1ρ relaxation time and measures of nucleus pulposus mechanics, and (2) to evaluate whether the quantitative relationship of T1ρ relaxation time with the degenerative grade and glycosaminoglycan content extend to more severe degeneration. It was hypothesized that the isometric swelling pressure and compressive modulus would be directly correlated with the T1ρ relaxation time and the apparent permeability would be inversely correlated with the T1ρ relaxation time

Topics: Scientific Articles
Publisher: Journal of Bone and Joint Surgery, Inc
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Provided by: PubMed Central
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