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Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis

By Joan S Lewis-Wambi, Helen R Kim, Chris Wambi, Roshani Patel, Jennifer R Pyle, Andres J Klein-Szanto and V Craig Jordan
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1980). A simple, rapid, and sensitive DNA assay procedure. Anal Biochem
  2. (2001). A: High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy. Breast Cancer Res Treat
  3. (1989). A: Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester.
  4. (1985). A: Origin and turnover of mitochondrial glutathione.
  5. (2008). A: The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol
  6. (2007). Allred DC: The estrogen paradox. Nat Clin Pract Endocrinol Metab
  7. (1999). BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity. Free Radic Biol Med
  8. (2008). Blackwell KL: Aromatase inhibitors for breast cancer: proven efficacy across the spectrum of disease. Clin Breast Cancer
  9. (2006). Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors. Cancer Res
  10. (1997). Chem
  11. (1993). DE: Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science
  12. (2006). Debatin KM: Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene
  13. (2006). Debatin KM: Targeting inhibitor of apoptosis proteins (IAPs) for diagnosis and treatment of human diseases. Recent Patents Anticancer Drug Discov
  14. (1944). E: Influence of synthetic oestrogens upon advanced malignant disease. BMJ
  15. (2008). Eguchi H: Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells. Adv Exp Med Biol
  16. EJ: Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-
  17. (2003). Ferguson-Miller S: Mitochondria: releasing power for life and unleashing the machineries of death. Cell
  18. (1998). Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact
  19. (1997). Induction of apoptosis by the transcription factor c-Jun.
  20. (2003). KJ: Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance. Cancer Res
  21. (2005). Kregel KC: Aging reduces responsiveness to BSO- and heat stressinduced perturbations of glutathione and antioxidant enzymes.
  22. (1998). ML: Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux. Biochem Biophys Res Commun
  23. (2001). Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes.
  24. (2000). Nussler AK: Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells. Cancer
  25. (2003). O'Dwyer PJ: Role of Jun and Jun kinase in resistance of cancer cells to therapy. Drug Resist Updat
  26. (2007). O'Malley BW: Selective estrogen-receptor modulators and antihormonal resistance in breast cancer.
  27. (1996). Ozols RF: Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer.
  28. (1995). Programmed cell death and Bcl-2 protection in very low oxygen. Nature
  29. (1997). Resistance to radiation-induced apoptosis in Bcl2-expressing cells is reversed by depleting cellular thiols. Oncogene
  30. (1999). Reynolds CP: Depletion of glutathione by buthionine sulfoxine is cytotoxic for human neuroblastoma cell lines via apoptosis. Exp Cell Res
  31. (1996). RF: Glutathione and drug resistance. Cancer Invest
  32. (2001). Santen RJ: Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol.
  33. (1986). Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs. Cancer Res
  34. (1996). Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2.
  35. (1989). Sinha BK: Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells. Cancer Res
  36. (1994). Spriggs DR: Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione.
  37. (2003). Tapiero H: The importance of glutathione in human disease. Biomed Pharmacother
  38. (2008). The 38th David A. Karnofsky lecture: the paradoxical actions of estrogen in breast cancer – survival or death? J Clin Oncol
  39. (1995). Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis.
  40. (1997). Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. Cancer Res
  41. (1996). Uthus EO: Suppression of plasma estradiol and progesterone concentrations by buthionine sulfoximine in female rats. Biochem Pharmacol
  42. (1995). VC: An estrogen-independent MCF-7 breast cancer cell line which contains a novel 80-kilodalton estrogen receptor-related protein. Cancer Res
  43. (1998). VC: Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth.
  44. (2005). VC: Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation.
  45. (2008). VC: Low-dose estrogen therapy to reverse acquired antihormonal resistance in the treatment of breast cancer. Clin Breast Cancer
  46. (1987). Vistica DT: Chemosensitization of L-phenylalanine mustard by the thiol-modulating agent buthionine sulfoximine. Cancer Res
  47. (1997). Wilding G: Phase I study of continuous-infusion L-S, R-buthionine sulfoximine with intravenous melphalan.

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