Skip to main content
Article thumbnail
Location of Repository

Functional characterization of E- and P-cadherin in invasive breast cancer cells

By David Sarrió, José Palacios, Marta Hergueta-Redondo, Gonzalo Gómez-López, Amparo Cano and Gema Moreno-Bueno
Topics: Research Article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    1. (2000). AB: Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion.
    2. (1991). Birchmeier W: E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.
    3. (2005). Bracke M: P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanoma. Cancer Res
    4. (1991). Cadherin cell adhesion receptors as a morphogenetic regulator. Science
    5. (2004). Carnahan RH: Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. Semin Cell Dev Biol
    6. (2003). Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta
    7. (2004). Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer
    8. (1996). Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell
    9. (2003). Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression. Embo J
    10. (2004). Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene
    11. (2001). Defective E-cadherin/catenin complexes in human cancer. Virchows Arch
    12. (2003). Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas. Cancer Res
    13. (1999). E-cadherin downregulation in cancer: fuel on the fire? Mol Med Today
    14. (1997). E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms.
    15. (2006). E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts. Exp Cell Res
    16. (2000). E-cadherin-catenin cellcell adhesion complex and human cancer.
    17. (2003). Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expression.
    18. (2003). Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability.
    19. (2002). Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer
    20. (2006). et al.: Genetic profiling of epithelial cells expressing e-cadherin repressors reveals a distinct role for snail, slug, and e47 factors in epithelial-mesenchymal transition. Cancer Res
    21. (1991). F: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell
    22. (2005). FC: P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Clin Cancer Res
    23. (2006). Garlick JA: E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion.
    24. (2003). Gumbiner BM: Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin.
    25. (2001). Gumbiner BM: E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner.
    26. (1999). Keshgegian AA: Pcadherin expression in breast carcinoma indicates poor survival. Cancer
    27. (2006). KR: Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn). Oncogene
    28. (2000). Longo DL: Truncation of the extracellular region abrogrates cell contact but retains the growthsuppressive activity of E-cadherin. Cancer Res
    29. (2008). Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res
    30. (2002). MJ: Phenotypic reversion or death of cancer cells by altering signaling pathways in threedimensional contexts.
    31. (1989). Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues.
    32. (2004). P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. Cancer Res
    33. (2005). P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Cancer Res
    34. (2000). Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.
    35. (2003). RA: Expression of P-cadherin, but not E-cadherin or N-cadherin, relates to pathological and functional differentiation of breast carcinomas. Mol Pathol
    36. (2000). Regulation of cadherin adhesive activity.
    37. (1999). Semb H: The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci
    38. (1997). Steinberg MS: Measurement of tumor cell cohesion and suppression of invasion by E- or P-cadherin. Cancer Res
    39. (1999). SW: Cadherin-11 is expressed in invasive breast cancer cell lines. Cancer Res
    40. (1999). The cadherin-catenin system: implications for growth and differentiation of endocrine tissues. Endocr Rev
    41. (2000). The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
    42. (2001). The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res
    43. (2001). The prognostic significance of P-cadherin in infiltrating ductal breast carcinoma. Mod Pathol
    44. (2004). The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation.
    45. (2005). Tulchinsky E: Immediate and delayed effects of E-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells. Mol Cell Biol
    46. (2004). Tumor-associated E-cadherin mutations do not induce Wnt target gene expression, but affect E-cadherin repressors. Lab Invest
    47. (2007). Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer
    48. (2006). Zhang B: D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness. Cancer Res

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.