Skip to main content
Article thumbnail
Location of Repository

The therapeutic potential of escitalopram in the treatment of panic disorder

By Mark H Townsend and Erich J Conrad

Abstract

Panic disorder is a chronic and disabling condition that is often accompanied by other psychiatric and medical conditions. The serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have been used effectively with panic disorder (PD) and conditions in which panic attacks frequently occur. Escitalopram is the most selective SSRI and a variety of evidence suggests it is of great value in the treatment of panic disorder. In this paper, we review the theoretical and practical implications of its use

Topics: Expert Opinion
Publisher: Dove Medical Press
OAI identifier: oai:pubmedcentral.nih.gov:2656325
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2001). A comparison of citalopram and paroxetine in the treatment of panic disorder: a randomized, singleblind study.
    2. (1998). A controlled, prospective, 1-year trial of citalopram in the treatment of panic disorder.
    3. (2006). A prospective study of escitalopram in the treatment of major depressive episodes in the presence or absence of anxiety. Depress Anxiety,
    4. (1995). Acute treatment response in outpatients with panic disorder: high versus low depressive symptoms. Ann Clin Psychiatry,
    5. (2007). Allosteric modulation of the effect of escitalopram, paroxetine and fl uoxetine: In-vitro and in-vivo studies.
    6. (2003). Antidepressant-induced mania: an overview of current controversies. Bipolar Dis,
    7. (2005). Brain serotonin 1A receptor binding in major depression is related to psychic and somatic anxiety.
    8. (2004). Clinical pharmacology of MAO inhibitors: safety and future.
    9. (2007). Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment.
    10. (1988). Clomipramine for panic disorder: the fi rst 10 weeks of along-term comparisons with imipramine.
    11. (1997). Determinants of pharmacologic treatment failure in panic disorder.
    12. (2004). Effects of chronic treatment with escitalopram or citalopram on extracellular 5-HT in the prefrontal cortex of rats: role of the 5-HT1A Receptors.
    13. (2004). Effi cacy and tolerability of escitalopram in 12- and 24-week treatment of social anxiety disorder. Depress Anxiety,
    14. (2004). Escitalopram in panic disorder: an open fl exibledose study.
    15. (2004). Escitalopram in the treatment of generalized anxiety disorder: double-blind, placebo-controlled, fl exible-dose study. Depression and Anxiety,
    16. (2005). Escitalopram in the treatment of generalized anxiety disorder. Expert Review of Neurotherapeutics,
    17. (2004). Escitalopram versus citalopram: the surprising role of the R-enantiomer.
    18. (2003). Escitalopram, the s-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities.
    19. (2002). Fixed dose trial of the single isomer SSRI escitalopram in depressed outpatients.
    20. (1998). Heart rate and blood pressure in panic disorder, major depression, and comorbid panic disorder and major depression. Psychiatry Res,
    21. (2007). Lexapro [package insert].
    22. (2005). Management of panic disorder.
    23. (1998). Mechanism of action of serotonin selective reuptake inhibitors: serotonin receptors and pathways mediate therapeutic effects and side effects.
    24. (2000). Neuroanatomical hypothesis of panic disorder, revisited.
    25. (2006). New possibilities of treatment for panic attacks in elderly patients: escitalopram versus citalopram.
    26. (2004). Newer antidepressants: review of effi cacy and safety of escitalopram and duloxetine.
    27. (2006). Panic and suicidal ideation and suicide attempts: results from the national comorbidity survey. Depress Anxiety,
    28. (2000). Panic: course, complications and treatment of panic disorder.
    29. (2006). Prediction of anti-panic properties of escitalopram in the Dorsal Periaqueductal Grey Model of Panic Anxiety.
    30. (2003). Psychotropic drugs, cardiac arrhythmia, and sudden death.
    31. (2006). Serotonin Function in Panic Disorder: Important, But Why? Neuropsychopharmacology,
    32. (1997). The effect of citalopram in panic disorder.
    33. (2005). The implications of medical and psychiatric comorbidity with panic disorder.
    34. (1997). The neuroanatomy of 5-HT dysregulation and panic disorder.
    35. (2005). The pharmacotherapy of panic disorder.
    36. (1997). Toward an integrated neurobiology of panic disorder.
    37. (1984). Treatment of panic disorder with imipramine alone.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.