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All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation

By Mélanie Kirchmeyer, Meriem Koufany, Sylvie Sebillaud, Patrick Netter, Jean-Yves Jouzeau and Arnaud Bianchi
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1983). AC: Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid. Science
  2. (2007). Acquisition, culture, and phenotyping of synovial fibroblasts. Methods Mol Med
  3. (1997). Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.
  4. (2002). AE: Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression.
  5. (1993). Akira S: Phosphorylation at threonine-235 by a rasdependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci USA
  6. (2008). Alten R: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet
  7. (2005). Animal models of rheumatoid arthritis and their relevance to human disease. Pathophysiology
  8. (1991). Breitman TR: Retinoylation of the cAMP-binding regulatory subunits of type I and type II cAMP-dependent protein kinases in HL60 cells. Arch Biochem Biophys
  9. (1993). C: RXR-dependent and RXR-independent transactivation by retinoic acid receptors. Nucleic Acids Res
  10. (1998). Chandraratna RA: Vitamin A and regulation of gene expression. Curr Opin Clin Nutr Metab Care
  11. (1995). CK: Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature
  12. (2002). Dual regulation of phosphorylation and dephosphorylation of C/EBPbeta modulate its transcriptional activation and DNA binding in response to growth hormone.
  13. (1996). Evain-Brion D: Retinoylation of the type II cAMP-binding regulatory subunit of cAMP-dependent protein kinase is increased in psoriatic human fibroblasts.
  14. (2003). Evolving concepts of rheumatoid arthritis.
  15. (1990). Expression of the interleukin 6 gene in rheumatoid synovial fibroblasts.
  16. (2006). Fang D: The proinflammatory cytokines IL1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/ 2-ETS1 pathway. Arthritis Res Ther
  17. (2006). Funauchi M: Anti-inflammatory effect of all-trans-retinoic acid in inflammatory arthritis. Clin Immunol
  18. (1999). GS: Jun N-terminal kinase in rheumatoid arthritis. J Pharmacol Exp Ther
  19. (2006). Interleukin-6 in rheumatoid arthritis. Curr Opin Rheumatol
  20. (1994). JA: Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts.
  21. (2007). LL: Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
  22. (1999). Manning AM: Signal transduction and transcription factors in rheumatic disease. Arthritis Rheum
  23. (2001). Molecular basis for designing selective modulators of retinoic acid receptor transcriptional activities. Curr Drug Targets Immune Endocr Metabol Disord
  24. (1997). Nagpal S: Retinoic acid receptor-nuclear factor-interleukin 6 antagonism. A novel mechanism of retinoid-dependent inhibition of a keratinocyte hyperproliferative differentiation marker.
  25. (2001). Nawata H: Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells. Hepatology
  26. (2007). New therapies for treatment of rheumatoid arthritis. Lancet
  27. (1996). Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels.
  28. (1993). Nuclear receptor/AP-1 interaction. Endocr Rev
  29. (1998). Ohsugi Y: Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum
  30. (1998). Okudaira H: Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1.
  31. (1999). Okudaira H: IL-6 synthesis by rheumatoid synoviocytes is autonomously upregulated at the transcriptional level. J Allergy Clin Immunol
  32. (1998). Okudaira H: Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factorkappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes.
  33. (1997). PS: Retinoid antagonism of NF-IL6: insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma. Mol Cell Biol
  34. (2000). Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kappa B but not C/EBP beta or c-Jun.
  35. (2005). Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNKAP-1 signaling in human chondrocytes. Biochem Pharmacol
  36. (2004). Retinoic acid signalling in the development of branchial arches. Curr Opin Genet Dev
  37. (2006). S: Functional characterization of an orphan nuclear receptor, RevErbAalpha, in chondrocytes and its potential role in osteoarthritis. Arthritis Rheum
  38. (2007). S: T cell selfreactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med
  39. (1998). Sakane T: Involvement of simultaneous multiple transcription factor expression, including cAMP responsive element binding protein and OCT-1, for synovial cell outgrowth in patients with rheumatoid arthritis. Ann Rheum Dis
  40. (1999). Shudo K: Effect of Am-80, a synthetic derivative of retinoid,
  41. (1988). Snick J: Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum
  42. (2005). Terlain B: Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. Arthritis Rheum
  43. (1993). Tosa T: Enhanced expression of interleukin 6 in rat and murine arthritis models.
  44. (2001). Tsukamoto H: Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease.
  45. (2000). Vincenti MP: Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNFdependent signal transduction in rabbit primary synovial fibroblasts. Cytokine

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