Skip to main content
Article thumbnail
Location of Repository

More intrinsic parameters should be used in assessing degeneration of articular cartilage with quantitative ultrasound

By Yong-Ping Zheng and Yan-Ping Huang


During the last decade, the quantitative ultrasound technique has been widely employed as a versatile modality to investigate a thin but crucial tissue layer – the articular cartilage. Previous studies provide information about the morphology and mechanical and acoustic properties of the tissue derived from ultrasound measurements and correlate them with cartilage degeneration. In a previous issue of Arthritis Research & Therapy, Kuroki and colleagues presented a study about the relationship between International Cartilage Repair Society grading and ultrasound echo magnitude, duration, and interval in human knee cartilage. We think indirect measurements of the intrinsic physical characteristics of cartilage, as reported in this study, should be interpreted more carefully as they can be affected by many experimental and physical factors. In this editorial, we offer our opinion that more intrinsic material parameters should be selected for the assessment of degeneration states of cartilage using quantitative ultrasound

Topics: Editorial
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2008). A: Noncontact evaluation of articular cartilage degeneration using a novel ultrasound water jet indentation system. Ann Biomed Eng
  2. (2008). AF: Altered osmotic swelling behavior of proteoglycandepleted bovine articular cartilage using high frequency ultrasound. Phys Med Biol
  3. (2002). An ultrasonic measurement for in vitro depth-dependent equilibrium strains of articular cartilage in compression. Phys Med Biol
  4. (1997). CM: The role of ultrasound in the assessment of osteoporosis: a review. Osteoporosis Int
  5. (1998). Evaluation of acoustical parameter sensitivity to age-related and osteoarthritic changes in articular cartilage using 50-MHz ultrasound. Ultrasound Med Biol
  6. (2001). Fu FH: An in situ calibration of an ultrasound transducer: a potential application for an ultrasonic indentation test of articular cartilage.
  7. (2008). HB: Ultrasonic assessment of progressive proteoglycan depletion of articular cartilage in real-time. Ultrasound Med Biol
  8. (2008). Iagnocco A: Ultrasound in the study and monitoring of osteoarthritis. Osteoarthritis Cartilage
  9. (2004). JS: Ultrasonic quantitation of superficial degradation of articular cartilage. Ultrasound Med Biol
  10. (2008). Jurvelin JS: In vitro comparison of time-domain, frequency-domain and wavelet ultrasound parameters in diagnostics of cartilage degeneration. Ultrasound Med Biol
  11. Jurvelin JS: Novel mechano-acoustic technique and instrument for diagnosis of cartilage degeneration. Physiol Meas 2002, 23:491-503.Page 3 of 3 (page number not for citation purposes)
  12. (2008). Kalunian K: Ultrasonography in osteoarthritis: recent advances and prospects for the future. Curr Opin Rheumatol
  13. (1996). Mak AF: An ultrasound indentation system for biomechanical properties assessment of soft tissues in vivo.
  14. (2004). Measurement of depth-dependence and anisotropy of ultrasound speed of bovine articular cartilage in vitro. Ultrasound Med Biol
  15. (2007). Oloyede A: Ultrasound assessment of articular cartilage: analysis of the frequency profile of reflected signals from naturally and artificially degraded samples. Connect Tissue Res
  16. (2007). Quantitative information from ultrasound evaluation of articular cartilage should be interpreted with care. Arthroscopy
  17. (2008). T: Ultrasound properties of articular cartilage in the tibio-femoral joint in knee osteoarthritis: relation to clinical assessment (ICRS grade). Arthritis Res Ther
  18. (2007). Ultrasound imaging for the rheumatologist – VIII. Ultrasound imaging in osteoarthritis. Clin Exp Rheumatol

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.