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The Final Player in the Coenzyme A Biosynthetic Pathway

By Nicholas O'Toole and Miroslaw Cygler


AbstractThe determination of the crystal structure of human phosphopantothenoylcysteine synthetase completes our knowledge of the enzyme structures involved in all steps of coenzyme A biosynthesis. This structure provides insight into the differences between bacterial and mammalian forms of the enzyme and may guide the structure-based development of novel antibacterial compounds

Publisher: Cell Press. Published by Elsevier Ltd.
Year: 2003
DOI identifier: 10.1016/S0969-2126(03)00161-8
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