Skip to main content
Article thumbnail
Location of Repository

Heterogeneous activation of the TGFβ pathway in glioblastomas identified by gene expression-based classification using TGFβ-responsive genes

By Xie L Xu and Ann M Kapoun
Topics: Research
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (1995). A: The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-beta, T-cell apoptosis, and the immune privilege of the brain.
  2. (1996). Akhurst RJ: TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell
  3. (1999). Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation.
  4. (1995). Brysch W: Effects of transforming growth factorbeta 1 on collagen synthesis, integrin expression, adhesion and invasion of glioma cells.
  5. (2006). CA: a Cancer Journal for Clinicians
  6. (1990). CC: TGF-beta 1 modulation of urokinase and PAI-1 expression in human bronchial epithelial cells.
  7. (2002). Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet
  8. (2000). Cheng SL: Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling.
  9. (2004). Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells.
  10. (2005). CS: Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Molecular & Cellular Biology
  11. (1998). DB: Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Molecular Biology of the Cell
  12. (2005). Derynck R: Specificity and versatility in tgf-beta signaling through Smads.
  13. (1992). Distribution of transforming growth factor-beta 1 in human astrocytomas. Human Pathology
  14. (1996). E: TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.
  15. (1998). elements in the promoter of human plasminogen activator inhibitor-type 1 gene.
  16. (2003). EP: Hierarchical model of gene regulation by transforming growth factor beta.
  17. (2006). et al.: Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors[see comment][erratum appears in
  18. (1995). Funa K: Enhanced expression of transforming growth factorbeta and its type-I and type-II receptors in human glioblastoma.
  19. (2005). Gene expression profiling and genetic markers in glioblastoma survival. Cancer Research
  20. (2005). Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.
  21. (2003). Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Research
  22. (2003). HL: Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Research
  23. (1999). Howe PH: TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway.
  24. (2007). Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness. Mol Pharmacol
  25. (2003). Interaction of transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF) in human glioma cells.
  26. (1989). Jr: Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas.
  27. (2006). Large- and small-molecule inhibitors of transforming growth factor-beta signaling.
  28. (2005). Loskutoff DJ: Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease. Thromb Haemost
  29. (1991). Loskutoff DJ: Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.
  30. (2001). Mauviel A: Identification of novel TGFbeta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.
  31. (2005). Moustakas A: TGFbeta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Molecular Biology of the Cell
  32. (2003). Ojeda SR: Activation of erbB-1 signaling in tanycytes of the median eminence stimulates transforming growth factor beta1 release via prostaglandin E2 production and induces cell plasticity.
  33. (2004). Phase II trial of gefitinib in recurrent glioblastoma.
  34. (2004). Protter AA: B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation. Circ Res
  35. (2003). PS: Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Research
  36. (2003). RB: Recent advances in the molecular genetics of primary gliomas. Current Opinion in Oncology
  37. (2003). Regulation of TG-interacting factor by transforming growth factor-beta.
  38. (2004). RV: Regulation of VEGF-A, VEGFR-I, thrombospondin-1, -2, and -3 expression in a human pituitary cell line (HP75) by TGFbeta1, bFGF, and EGF. Endocrine
  39. (2006). RW: TGF-beta1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation.
  40. (2004). SF: Gene expression profiling of gliomas strongly predicts survival. Cancer Research
  41. (1999). TA: TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.
  42. (2005). TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance[see comment]. Cancer Cell
  43. (1999). The role for transforming growth factor-beta (TGFbeta) in human cancer. Critical Reviews in Oncogenesis
  44. (1997). Transforming growth factor-beta and cancer: a lovehate relationship? Oncology Research
  45. (2006). Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression. Mol Pharmacol
  46. (2000). Widegren B: Expression of TGFbeta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma.
  47. (2001). Wong WH: Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data.
  48. (2003). Zhang W: Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes. Cancer Research

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.