Skip to main content
Article thumbnail
Location of Repository

Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease

By Ann E. Tilley, Ben-Gary Harvey, Adriana Heguy, Neil R. Hackett, Rui Wang, Timothy P. O'Connor and Ronald G. Crystal

Abstract

Rationale: The airway epithelium of smokers is subject to a variety of mechanisms of injury with consequent modulation of epithelial regeneration and disordered differentiation. Several signaling pathways, including the Notch pathway, control epithelial differentiation in lung morphogenesis, but little is known about the role of these pathways in adults

Topics: B. Chronic Obstructive Pulmonary Disease
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:2654975
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.