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Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease

By Ann E. Tilley, Ben-Gary Harvey, Adriana Heguy, Neil R. Hackett, Rui Wang, Timothy P. O'Connor and Ronald G. Crystal


Rationale: The airway epithelium of smokers is subject to a variety of mechanisms of injury with consequent modulation of epithelial regeneration and disordered differentiation. Several signaling pathways, including the Notch pathway, control epithelial differentiation in lung morphogenesis, but little is known about the role of these pathways in adults

Topics: B. Chronic Obstructive Pulmonary Disease
Publisher: American Thoracic Society
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Provided by: PubMed Central
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