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Testing significance relative to a fold-change threshold is a TREAT

By Davis J. McCarthy and Gordon K. Smyth


Motivation: Statistical methods are used to test for the differential expression of genes in microarray experiments. The most widely used methods successfully test whether the true differential expression is different from zero, but give no assurance that the differences found are large enough to be biologically meaningful

Topics: Original Papers
Publisher: Oxford University Press
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Provided by: PubMed Central
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