Skip to main content
Article thumbnail
Location of Repository

Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations

By Fumihiko Nakamura, Outi Heikkinen, Olli T. Pentikäinen, Teresia M. Osborn, Karen E. Kasza, David A. Weitz, Olga Kupiainen, Perttu Permi, Ilkka Kilpeläinen, Jari Ylänne, John H. Hartwig and Thomas P. Stossel
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (1992). Actin-binding protein requirement for cortical stability and efficient locomotion.
  2. Akyurek LM (2007) Filamins in cardiovascular development.
  3. (2004). Annila A
  4. (1995). Antigen-antibody interactions: how affinity and kinetics affect assay design and selection procedures.
  5. (1996). AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR.
  6. (2004). BODIL: a molecular modeling environment for structure-function analysis and drug design.
  7. (2005). Ca2+ and calmodulin regulate the binding of filamin A to actin filaments.
  8. (2006). Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum Mol
  9. (2002). Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces.
  10. (1993). Comparative protein modelling by satisfaction of spatial restraints.
  11. (2002). Comparison of filamin A-induced cross-linking and Arp2/3 complex-mediated branching on the mechanics of actin filaments.
  12. (2007). Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23–24 dimer.
  13. (2002). Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.
  14. (1996). Errors in protein structures.
  15. (2006). Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
  16. (2001). Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells.
  17. (2005). Filamin A: phenotypic diversity.
  18. (2007). Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.
  19. (2001). Filamins as integrators of cell mechanics and signalling.
  20. (2006). Filamins: promiscuous organizers of the cytoskeleton.
  21. (2006). FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.
  22. (2006). Frontometaphyseal dysplasia: mutations in FLNA and phenotypic diversity.
  23. (1999). Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients.
  24. (2005). High affinity interaction with filamin A protects against calcium-sensing receptor degradation.
  25. (2008). Integrin {beta}2 phosphorylation on THR758 acts as a molecular switch to regulate 14-3-3 and filamin binding.
  26. (2002). Intraresidual HNCA: An experiment for correlating only intraresidual backbone resonances.
  27. (2006). Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure.
  28. (1996). MOLMOL: a program for display and analysis of macromolecular structures.
  29. (1998). Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.
  30. (2007). Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy.
  31. (2004). Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis.
  32. (2006). Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells.
  33. (2002). Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA.
  34. (2008). Sparky 3.
  35. (2005). Structural basis for vertebrate filamin dimerization.
  36. (2007). Structural basis of filamin A functions.
  37. (2005). The design of coiled-coil structures and assemblies.
  38. (2006). The molecular basis of filamin binding to integrins and competition with talin.
  39. (2002). The PyMOL Molecular Graphics System.
  40. (1999). The small GTPase RalA targets filamin to induce filopodia.
  41. (2006). The structure of the GPIb-filamin A complex.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.