Skip to main content
Article thumbnail
Location of Repository

Characterization of Arterial Wave Reflection in Healthy Bonnet Macaques: Feasibility of Applanation Tonometry

By Jason Lazar, Ghazanfar Qureshi, Haroon Kamran, Leonard A. Rosenblum, John G. Kral and Louis Salciccioli

Abstract

Nonhuman primates are commonly used in cardiovascular research. Increased arterial stiffness is a marker of subclinical atherosclerosis and higher CV risk. We determined the augmentation index (AI) using applanation tonometry in 61 healthy monkeys (59% female, age 1–25 years). Technically adequate studies were obtained in all subjects and required 1.5 ± 1.3 minutes. The brachial artery provided the highest yield (95%). AI was correlated with heart rate (HR) (r = −0.65, P < .001), crown rump length (CRL) (r = 0.42, P = .001), and left ventricular (LV) mass determined using echocardiography (r = 0.52, P < .001). On multivariate analysis, HR (P < .001) and CRL (P = .005) were independent predictors of AI (R2 = 0.46, P < .001). Body Mass Index (BMI) and AI were independent predictors of higher LV mass on multivariate analysis (P < .001 and P = .03). In conclusion, applanation tonometry is feasible for determining AI. Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:2654075
Provided by: PubMed Central

Suggested articles

Citations

  1. (2004). A .v a nT r i j p
  2. (2001). A crosslink breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys,”
  3. (1978). Altered myocardial function and collagen in diabetic rhesus monkeys on atherogenic diet,”
  4. (1991). Cardiovascular effects in bonnet monkeys (Macaca radiata) of a cassava-based protein-deficient diet,”
  5. (1991). Cardiovascular, respiratory, and analgesic effects of fentanyl
  6. Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms,”
  7. (2005). Comparative anatomical study of the autonomic cardiac nervous system in macaque monkeys,”
  8. Coronary artery distribution in bonnet monkeys
  9. (1976). Determination of body surface area in the rhesus monkey,”
  10. (1985). e n ,B .C .H a n s e n ,a n dB .L .M e t z g e r ,“ A d i p o s i t y , anthropometric measures, and plasma insulin levels of rhesus monkeys,”
  11. (2005). Early appearance of the metabolic syndrome in socially reared bonnet macaques,”
  12. (1987). Echocardiographic left ventricular mass and function
  13. (2005). Echocardiography of Rhesus monkeys (Macaca mulatta),”
  14. (1997). Estimation of Central aortic pressure waveform by mathematical transformation of radial tonometry pressure: validation of generalized transfer function,”
  15. (1978). F a r r a r ,H .D .G r e e n ,M .G .B o n d ,W .D .W a g n e r ,a n dR . A. Gobbe´ e, “Aortic pulse wave velocity, elasticity, and composition in a nonhuman primate model of atherosclerosis,”
  16. (2001). Gender differences in the timing of arterial wave reflection beyond differences in body height,”
  17. (2007). Indices of pulse wave analysis are better predictors of left ventricular mass reduction than cuff pressure,”
  18. (1997). K o r c a r z ,P .A .P a d r i d
  19. (2008). Left ventricular systolic and diastolic function in healthy adult bonnet macaques (Macaca radiata): new echocardiographic indices in old world monkeys,”
  20. (2001). Left ventricular, systemic arterial, and baroreflex responses to ketamine and TEE in chronically instrumented monkeys,”
  21. (2002). o u t o u yr i e ,A .I .T r o p e a n o ,R .A s m a r ,e ta l . ,“ A o rt i cs t i ffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study,”
  22. (2007). Relationship between aortic atherosclerosis and non-invasive measures of arterial stiffness,”
  23. (1986). S w i n d l e ,J .R .B l u m ,a n dJ .L .W e i s s ,“ M o r p h o m e t r i c studies of the heart in normal rhesus monkey (Macaca mulatta),”
  24. S w i n d l e ,J .R .B l u m ,S .D .L i m a ,a n dJ .L .W e i s s , “Spontaneous mitral valve prolapse in a breeding colony of rhesusmonkeys,”Circulation,vol.71,no.1,pp.146–153,1985.
  25. (1989). The application of the doppler echocardiography for the determination of the prompt hemodynamic reactors in the rhesus monkeys,”
  26. The influence of heart rate on augmentation index and central arterial pressure in humans,”
  27. (1992). Vasculopathic and cardiomyopathic changes induced by low-protein high-carbohydrate tapioca based diet in Bonnet monkey: vasculopathic and cardiomyopathic changes in induced malnutrition,”
  28. (1991). W i l l i a m s ,M .S .A n t h o n y ,a n dT .B .C l a r k s o n ,“ C o r o n a r y heart disease in rhesus monkeys with diet-induced coronary artery atherosclerosis,”

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.