Skip to main content
Article thumbnail
Location of Repository

cGMP-Dependent Protein Kinase I Is Crucial for Angiogenesis and Postnatal Vasculogenesis

By Alexandra Aicher, Christopher Heeschen, Susanne Feil, Franz Hofmann, Michael E. Mendelsohn, Robert Feil and Stefanie Dimmeler
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2005). A heretical view on the role of NO and cGMP in vascular proliferative diseases.
  2. (2003). A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells.
  3. (2003). A Stimulatory Role for cGMPDependent Protein Kinase in Platelet Activation.
  4. (2008). Activation of endothelial nitric oxide synthase is critical for erythropoietin-induced mobilization of progenitor cells.
  5. (2008). Anemia and splenomegaly in cGKI-deficient mice.
  6. (2000). Angiogenesis monitored by perfusion with a space-filling microbead suspension. Mol Ther 1: 82–87. cGKI for
  7. (1977). cGMP stimulation of stem cell proliferation.
  8. (2002). cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium.
  9. (2006). cGMPdependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes.
  10. (2008). Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension.
  11. (2003). Cyclic GMPdependent protein kinases and the cardiovascular system: insights from genetically modified mice.
  12. (1998). Defective smooth muscle regulation in cGMP kinase I-deficient mice.
  13. (2007). Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha.
  14. (2005). Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina.
  15. (2007). Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes.
  16. (2003). Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 9: 1370–1376. cGKI for
  17. (2003). Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury.
  18. (1998). Evidence for circulating bone marrow-derived endothelial cells.
  19. (2006). Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy.
  20. (1995). Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin.
  21. (2006). Function of cGMPdependent protein kinases as revealed by gene deletion.
  22. (2003). Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/ PKG.
  23. (2008). High blood pressure arising from a defect in vascular function.
  24. (2004). Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood.
  25. (1999). Increased adhesion and aggregation of platelets lacking cyclic guanosine 39,59-monophosphate kinase I.
  26. (1999). Ischemiaand cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization.
  27. (1997). Mechanisms of angiogenesis.
  28. (2001). Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis.
  29. (2006). Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes.
  30. (2003). Nitric Oxide Enhances Angiogenesis via the Synthesis of Vascular Endothelial Growth Factor and cGMP After Stroke in the Rat.
  31. (1998). Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
  32. (2004). Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis.
  33. (2004). Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease.
  34. (1999). Regulation of myosin phosphatase by a specific interaction with cGMPdependent protein kinase Ialpha.
  35. (1996). Signalling by cGMP-dependent protein kinases.
  36. (2003). Significance and therapeutic potential of the natriuretic peptides/cGMP/ cGMP-dependent protein kinase pathway in vascular regeneration.
  37. (2007). Sildenafil promotes ischemia-induced angiogenesis through a PKG-dependent pathway.
  38. (2007). Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.
  39. (2004). Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase.
  40. (1988). The disc angiogenesis system.
  41. (2007). The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway.
  42. (1998). Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.