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Prognostic value of prostate circulating cells detection in prostate cancer patients: a prospective study

By P Eschwège, S Moutereau, S Droupy, R Douard, J-L Gala, G Benoit, M Conti, P Manivet and S Loric

Abstract

In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients presented blood prostate cell shedding preoperatively and intraoperatively (group I). Of the 98 preoperatively negative patients, 53 (54%) remained negative (group II) and 45 (46%) became intraoperatively positive (group III). Median biological and clinical recurrence-free time was far shorter in group I (36.2 months, P<0.0001) than in group II (69.6 months) but did not significantly differ in group II and III (69.6 months vs 65.0). Such 5-year follow-up data show that preoperative circulating prostate cells are an independent prognosis factor of recurrence. Moreover, tumour handling induces cancer-cell seeding but surgical blood dissemination does not accelerate cancer evolution

Topics: Clinical Studies
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2653745
Provided by: PubMed Central
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    Citations

    1. (2009). Cardiovasc Surg 119: 899–905 Prostate circulating cells detection P Eschwe `ge et al
    2. (1995). Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy. Lancet 346: 1528–1530 Lintula
    3. (2002). Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal cancer surgery.

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