Skip to main content
Article thumbnail
Location of Repository

Critical assessment of methods of protein structure prediction—Round VII

By John Moult, Krzysztof Fidelis, Andriy Kryshtafovych, Burkhard Rost, Tim Hubbard and Anna Tramontano


This paper is an introduction to the supplemental issue of the journal PROTEINS, dedicated to the seventh CASP experiment to assess the state of the art in protein structure prediction. The paper describes the conduct of the experiment, the categories of prediction included, and outlines the evaluation and assessment procedures. Highlights are improvements in model accuracy relative to that obtainable from knowledge of a single best template structure; convergence of the accuracy of models produced by automatic servers toward that produced by human modeling teams; the emergence of methods for predicting the quality of models; and rapidly increasing practical applications of the methods

Topics: CASP Introduction—Round VII
Publisher: Wiley Subscription Services, Inc., A Wiley Company
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    1. A large-scale experiment to assess protein structure prediction methods.
    2. Assessment of CASP7 predictions for template-based modeling targets. Proteins 2007;69(Suppl 8):38–56.
    3. Assessment of CASP7 predictions in the high accuracy template-based modeling category.
    4. Assessment of CASP7 structure predictions for template-free targets.
    5. Assessment of disorder predictions
    6. Assessment of intramolecular contact predictions for CASP7. Proteins 2007;69(Suppl 8):152–158.
    7. Assessment of predictions in the Model Quality Assessment category. Proteins 2007;69(Suppl 8):175–183.
    8. Assessment of predictions submitted for the CASP7 function prediction category. Proteins 2007;69(Suppl 8):165–174.
    9. Automated server predictions
    10. (2007). Automatic procedure for using models of proteins in molecular replacement.
    11. Critical assessment of methods of protein structure prediction (CASP)— round 6. Proteins 2005;61(Suppl 7):3–7.
    12. Critical assessment of methods of protein structure prediction (CASP)—round IV. Proteins 2001;45(Suppl 5):2–7.
    13. Critical assessment of methods of protein structure prediction (CASP)—round V. Proteins 2003;53(Suppl 6):334–339.
    14. Critical assessment of methods of protein structure prediction (CASP): round III. Proteins 1999;37(Suppl 3):2–6.
    15. Design of a novel globular protein fold with atomic-level accuracy.
    16. Domain definition and target classification for CASP7. Proteins 2007;69(Suppl 8):10–18.
    17. Evaluating the usefulness of protein structure models for molecular replacement. Bioinformatics 2005;21(Suppl 2):ii72–ii76.
    18. Evaluation of domain prediction
    19. Ezkurdia I. Assessment of predictions submitted for the CASP7 domain prediction category.
    20. Intrinsically unstructured proteins and their functions.
    21. LGA: a method for finding 3D similarities in protein structures.
    22. New tools and expanded data analysis capabilities at the Protein Structure Prediction Center. Proteins 2007;69(Suppl 8):19–26.
    23. Prediction of gobal and local model quality in
    24. Progress over the first decade of CASP experiments.
    25. Revisiting the prediction of protein function at CASP6.
    26. (2005). Tramontano A The prediction of protein function at CASP6. Proteins
    27. Worth the effort. An account of the Seventh Meeting of the Worldwide Critical Assessment of Techniques for Protein Structure Prediction.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.