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The Tail of Mycolic Acids

By Jeff Zhiqiang Lu and Sean T. Prigge

Abstract

The FabH enzyme from M. tuberculosis binds the acyl tail of large substrates at the end of a buried hydrophobic tunnel. Sachdeva et al. (2008) use reactive chemical probes and X-ray crystallography to show that substrates can bind to an open state of FabH without threading through the tunnel

Publisher: Elsevier Ltd.
Year: 2008
DOI identifier: 10.1016/j.chembiol.2008.04.001
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