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The Tail of Mycolic Acids

By Jeff Zhiqiang Lu and Sean T. Prigge


The FabH enzyme from M. tuberculosis binds the acyl tail of large substrates at the end of a buried hydrophobic tunnel. Sachdeva et al. (2008) use reactive chemical probes and X-ray crystallography to show that substrates can bind to an open state of FabH without threading through the tunnel

Publisher: Elsevier Ltd.
Year: 2008
DOI identifier: 10.1016/j.chembiol.2008.04.001
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