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Generation of electrospray from a solution predeposited on optical fibers coiled with a platinum wire

By Chih-Pin Kuo, Cheng-Hui Yuan and Jentaie Shiea

Abstract

AbstractThis study examines the feasibility of generating electrospray directly from the tip of two optical fibers bound together with Teflon tape. This approach does not require a capillary and syringe pump. The electrospray source is simply constructed by coiling the two optical fibers with a platinum (Pt) wire. The optical fibers extend beyond the Pt coil for approximately 1 cm. The sample solution is predeposited on the Pt coil by a micropipette. As the high voltage required for electrospray is applied to the coil, the sample solution moves along the grooves between the two optical fibers. A stable electrospray is subsequently generated at the tip of the fibers. The mass spectra of insulin, lysozyme, and ubiquitin are exactly the same as those obtained by conventional electrospray using a capillary and syringe pump. Rapid determination of the active ingredient in a tablet by this technique is demonstrated

Publisher: American Society for Mass Spectrometry. Published by Elsevier B.V.
Year: 2000
DOI identifier: 10.1016/S1044-0305(00)00111-2
OAI identifier:

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