Article thumbnail

Acute kidney injury in burns: a story of volume and inflammation

By Kirsten Colpaert and Eric A Hoste


Acute kidney injury occurs in approximately one-quarter to one-third of patients with major burn injury. Apart from the usual suspects – such as older age, severity of burn injury, sepsis and multiple organ dysfunction – volume overload probably has an important role in the pathogenesis of acute kidney injury

Topics: Commentary
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2007). A: Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit Care
  2. (2008). Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study. Crit Care
  3. (2004). and the ADQI workgroup: Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs:
  4. (2003). C: The pathogenesis of septic acute renal failure. Curr Opin Crit Care
  5. (2005). Caushaj PF: A prospective, randomized evaluation of intra-abdominal pressures with crystalloid and colloid resuscitation in burn patients.
  6. (2005). Colardyn FA: Assessment of renal function in recently admitted critically ill patients with normal serum creatinine. Nephrol Dial Transplant
  7. (2007). Decreased fluid volume to reduce organ damage: a new approach to burn shock resuscitation? A preliminary study. Resuscitation
  8. (2007). DN: Burn size determines the inflammatory and hypermetabolic response. Crit Care
  9. (2008). GF: The Parkland formula under fire: is the criticism justified?
  10. (1996). Horwitz RI: The effect of acute renal failure on mortality. A cohort analysis.
  11. (2000). Intra-abdominal hypertension and abdominal compartment syndrome in burn patients.
  12. (2007). MM: An assessment of the RIFLE criteria for acute renal failure in severely burned patients [letter]. Nephrol Dial Transplant
  13. (2007). Parikh CR: Contribution of acute kidney injury toward morbidity and mortality in burns: a contemporary analysis.
  14. (2006). Renal blood flow in experimental septic acute renal failure. Kidney Int
  15. (2007). S: The abdominal compartment syndrome in patients with burn injury. Acta Clin Belg
  16. (2008). Schurgers M: Epidemiology of AKI: how big is the problem? Crit Care Med
  17. (2006). Sugimoto H: Hypertonic lactated saline resuscitation reduces the risk of abdominal compartment syndrome in severely burned patients.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.