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Kinetic proofreading of gene activation by chromatin remodeling

By R. Blossey and H. Schiessel

Abstract

Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodelers, and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gene regulation in eukaryotes based on the combinatorical interactions of chromatin modifiers

Topics: Qubits
Publisher: HFSP Publishing
OAI identifier: oai:pubmedcentral.nih.gov:2645567
Provided by: PubMed Central
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