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Na+-dependent fructose transport via rNaGLT1 in rat kidney

By Naoshi Horiba, Satohiro Masuda, Chiharu Ohnishi, Daisuke Takeuchi, Masahiro Okuda and Ken-ichi Inui


AbstractWe found a system of Na+-dependent uptake of fructose by rat renal brush-border membrane vesicles. It consisted of two saturable components, and was thought to involve at least two transporters. rNaGLT1, a novel glucose transporter in rat kidney, showed fructose uptake as well as α-methyl-D-glucopyranoside uptake by transfected HEK293 cells. The features of the lower affinity type of fructose transporter in the brush-border membranes, such as affinity and substrate recognition, were very comparable with those of rNaGLT1-transfected HEK293 cells. These results indicated that rNaGLT1 is a primary fructose transporter in rat renal brush-border membranes

Publisher: Published by Elsevier B.V.
Year: 2003
DOI identifier: 10.1016/S0014-5793(03)00600-8
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