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Antifungal activity of Ocimum sanctum Linn. (Lamiaceae) on clinically isolated dermatophytic fungi

By S Balakumar, S Rajan, T Thirunalasundari and S Jeeva


AbstractObjectiveTo assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi.MethodsAntifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined.ResultsOcimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200 μg/mL. MIC and MFC were high with water fraction (200 μg/mL) against dermatophytic fungi used.ConclusionsOcimum sanctum has antifungal activity, and the leaf extracts may be a useful source for dermatophytic infections

Publisher: Hainan Medical College. Published by Elsevier (Singapore) Pte Ltd.
Year: 2011
DOI identifier: 10.1016/S1995-7645(11)60166-1
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