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Synthesis and preliminary biological evaluation of a compound library of triazolylcyclitols

By Gonzalo Carrau, Carine C. Drewes, Ana Lúcia B. Shimada, Ana Bertucci, Sandra H.P. Farsky, Helio A. Stefani and David Gonzalez


AbstractA small library of compounds was prepared by a combination of toluene dioxygenase (TDO)-catalyzed enzymatic dihydroxylation and copper(I)-catalyzed Hüisgen cycloaddition. Some compounds were obtained by coupling an alkyne and a conduritol derivative, while more complex structures were obtained by a double Hüisgen reaction of a dialkyne and two molecules of the cyclitol. The compounds were fully characterized and subjected to preliminary biological screening

Publisher: Elsevier Ltd.
Year: 2013
DOI identifier: 10.1016/j.bmc.2013.04.084
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