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A Polyamine Twist on Hedgehog Signaling

By Xuesong Zhao and Rosalind A. Segal


The Hedgehog pathway plays important roles in embryonic development and oncogenesis, but how it affects metabolism is less clear. D’Amico et al. (2015) now demonstrate that the Hedgehog pathway regulates translation of ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural precursor cells and in brain tumors

Publisher: Elsevier Inc.
Year: 2015
DOI identifier: 10.1016/j.devcel.2015.09.024
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