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Transcriptional cooperativity: bending over backwards and doing the flip

By Tom K Kerppola

Abstract

AbstractThe structures of the NFAT1–Fos–Jun–ARRE2 and MATα2–MCM1–STE6 transcription regulatory complexes reveal changes in protein conformation and DNA bending. Studies of the interaction between Fos–Jun and NFAT1 in solution corroborate the crystallographic analysis. These results manifest the flexibility required for cooperative binding to composite regulatory elements

Publisher: Elsevier Science Ltd.
Year: 1998
DOI identifier: 10.1016/S0969-2126(98)00057-4
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