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Investigation of the Antimetastatic Effects of Agents that Inhibit Cell Adhesion or Protein Glycosylation

By Martin J. Humphries, Kazue Matsumoto, Sandra L. White and Kenneth Olden


In this overview the authors describe their recent attempts to specifically interfere with the metastatic spread of B16-F10 melanoma cells. Using the experimental metastasis model system, inhibitory effects of (1) coinjection of cells with synthetic peptides derived from the glycoprotein fibronectin, which possess the ability to disrupt cell adhesion, and (2) treatment of cells with inhibitors of protein glycosylation and oligosaccharide processing have been examined

Topics: Original Communications
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Provided by: PubMed Central
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