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Two Ways to Get Mad at Kinetochores

By Patrick Meraldi

Abstract

The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids once all chromosomes are attached via kinetochores by microtubules of the mitotic spindle. Reporting in Developmental Cell, Silió et al. (2015) show that in human cells the signaling cascade controlling the checkpoint operates through two separate branches

Publisher: Elsevier Inc.
Year: 2015
DOI identifier: 10.1016/j.devcel.2015.11.021
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