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Endocrine abnormalities in human temporal lobe epilepsy.

By B. B. Gallagher

Abstract

Patients with temporal lobe epilepsy secrete ACTH at higher rates and in greater amounts than normal subjects. Temporal lobectomy restores ACTH secretion to normal amounts and rates. The ACTH secretion in temporal lobe epilepsy is independent of anticonvulsant drug effect and seizure frequency. Electrical stimulation of medial temporal lobe structures in patients with temporal lobe epilepsy affected ACTH secretion in a manner consistent with the hypothesis that ACTH secretion is regulated by tonic inhibition. A defect in the excitatory and/or inhibitory components of this regulatory process appears to exist in temporal lobe epilepsy

Topics: Research Article
Publisher: Yale Journal of Biology and Medicine
OAI identifier: oai:pubmedcentral.nih.gov:2590313
Provided by: PubMed Central

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Citations

  1. (1973). ACTH and cortisol secretory patterns in man.
  2. (1976). Adrenal hyperplasia in epileptic patients.
  3. (1985). al: Neurotransmitter regulation of anterior pituitary hormones. Pharmocal Rev 37:249-332,
  4. (1984). al: Pituitary and adrenal function in epileptic patients. Epilepsia 25:683-689,
  5. al: The effect of electrical stimulation of medial temporal lobe structures, in epileptic patients, upon ACTH, prolactin, and growth hormone. Neurology,

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