Article thumbnail
Location of Repository

Depression and Type 2 Diabetes Over the Lifespan: A meta-analysis

By Briana Mezuk, William W. Eaton, Sandra Albrecht and Sherita Hill Golden


OBJECTIVE—It has been argued that the relationship between depression and diabetes is bi-directional, but this hypothesis has not been explicitly tested. This systematic review examines the bi-directional prospective relationships between depression and type 2 diabetes

Topics: Reviews/Commentaries/ADA Statements
Publisher: American Diabetes Association
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2007). A review of the evidence for a neuroendocrine link between stress, depression and diabetes mellitus. Curr Diabetes Rev 3:252–259,
  2. (2006). A: Prevalent and incidence depression in community-dwelling elderly persons with diabetes mellitus: results from the ZARADEMP project.
  3. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis.
  4. (1994). Age differences in the symptoms of depression: a latenttraitanalysis.JGerontology49:251– 264,
  5. (2005). Association: Diabetes Fact Sheet. Available from http://wwwdiabetesorg/about-diabetesjsp,
  6. (2004). Buntinx F: Is depression related tosubsequentdiabetesmellitus?ActaPsychiatr Scand 110:178–183,
  7. (2000). Depression and poor glycemic control: a meta-analyticreviewoftheliterature.DiabetesCare 23:934–942,
  8. (1996). Depression and risk for onset of typeIIdiabetes:aprospectivepopulationbased study.
  9. Depressive symptoms and occurrence of type 2 diabetes among Japanese men. Diabetes Care 22:1071–1076,
  10. Depressive symptoms and risk of type 2 diabetes
  11. (2008). Depressive symptoms and the risk of type 2 diabetes mellitus
  12. (2004). Depressive symptoms, insulin resistance and risk of diabetes in women at midlife.
  13. (2008). Diabetes mellitus, glycemic control, and incident depressive symptoms among 70- to 79-year-old persons: the health, aging and body composition study.
  14. (2004). E: A prospective study of type 2 diabetes and depressive symptoms in the elderly: the Rancho Bernardo Study. Diabet Med 21: 1185–1191,
  15. (2005). EE: Lifetime prevalence and age-of-onset distributions of DSM-IVdisordersintheNationalComorbidity Survey Replication. Arch Gen Psychiatry 62:593–602,
  16. (2007). EngumA:Theroleofdepressionandanxiety in onset of diabetes in a large population-based study.
  17. (2002). Epidemiologic evidence on comorbidity of depression and diabetes.
  18. (1971). FortmannS:Symptomsofdepressionasa risk factor for incident diabetes: findings from the National Health and Nutrition Examination Epidemiologic Follow-Up Study,
  19. (2004). Geriatric depression and vascular diseases: what are the links? J Affect Disord 81:1–16,
  20. (2005). High incidence of diabetes in men with sleep complaints or short sleep duration. Diabetes Care 28:2762–2767,
  21. (2008). K: The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults. Gen Hosp Psychiatry 30:127– 137,
  22. (2008). Knowler W: Elevated depressive symptoms, antidepressant use, and risk of developing diabetes during the Diabetes Prevention Program. Diabetes Care 31: 420–426,
  23. (2005). Long-term risk for depressive symptoms after a medical diagnosis. Arch Intern Med 165:1260–1266,
  24. (2001). Lustman P: Association of depression and diabetes complications: a meta-analysis. Psychosom Med 63:619– 630,
  25. (2000). Major depression and impaired glucose tolerance. Exp Clin Endocrinol Diabetes 108:187–190,
  26. (2005). MillerE,LeslieD,RosenheckR:Incidence of new-onset diabetes mellitus among patients receiving atypical neuroleptics in the treatment of mental illness.
  27. (1986). N: Meta-analysis in clinical trials. Control Clin Trials 7:177– 188,
  28. (2004). PattonSanfordC,NeitoF,BranctiF:Depressive symptoms and the risk of type 2 diabetes: the Atherosclerosis Risk in Communities Study. Diabetes Care 27: 429–435,
  29. (2006). Pouwer F: Depression as a risk factorfortheonsetoftype2diabetesmellitus:ameta-analysis.Diabetologia49:837– 845,
  30. (2004). Predictors of the onset of depressive symptoms in patients with heart failure.
  31. (2004). Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study.
  32. (2007). Siscovick D: Longitudinal association between depressive symptoms and incident type 2 diabetes mellitus in older adults. Arch Intern Med 167:802–807,
  33. (2000). Testosterone, sex hormone-binding globulin and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care 23:490–494,
  34. The prevalence of comorbid depression in adults with diabetes: a metaanalysis. Diabetes Care 24:1069–1078,
  35. Tweedie R: Trim and fill: a simple funnel-plot-based approach of testing and adjusting for publication bias in meta-analysis.
  36. Type 2 diabetes does not increase risk of depression.
  37. (2006). Vascular risk factors and incident late-life depression in a Korean population.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.