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Critical Role for TSLC1 Expression in the Growth and Organ Infiltration of Adult T-Cell Leukemia Cells In Vivo▿

By M. Zahidunnabi Dewan, Naofumi Takamatsu, Tomonori Hidaka, Kinta Hatakeyama, Shingo Nakahata, Jun-ichi Fujisawa, Harutaka Katano, Naoki Yamamoto and Kazuhiro Morishita

Abstract

Adult T-cell leukemia (ATL) is associated with human T-cell leukemia virus type 1 infection. The tumor suppressor lung cancer 1 (TSLC1) gene was previously identified as a novel cell surface marker for ATL, and this study demonstrated the involvement of TSLC1 expression in tumor growth and organ infiltration of ATL cells. In experiments using NOD/SCID/γcnull mice, both leukemia cell lines and primary ATL cells with high TSLC1 expression caused more tumor formation and aggressive infiltration of various organs of mice. Our results suggest that TSLC1 expression in ATL cells plays an important role in the growth and organ infiltration of ATL cells

Topics: Transformation and Oncogenesis
Publisher: American Society for Microbiology (ASM)
OAI identifier: oai:pubmedcentral.nih.gov:2583669
Provided by: PubMed Central
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