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Real-Time PCR Detection of gyrA and parC Mutations in Streptococcus pneumoniae▿

By S. Page, F. Vernel-Pauillac, O. O'Connor, S. Bremont, F. Charavay, P. Courvalin, C. Goarant and S. Le Hello


Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes. This assay provides a useful tool for both clinical and epidemiological use

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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