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γ-Subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence

By Narendra Tuteja and Debora B. Farber

Abstract

AbstractThe cDNA nucleotide and corresponding amino acid sequences of the γ-subunit of cyclic-GMP phosphodiesterase (cGMP-PDEγ) from mouse retina have been determined. The cDNA translated region was found to be 91.5% homologous to the cDNA coding region for the enzyme from bovine retina [(1986) FEBS Lett. 204, 288–292]. On Northern blots of normal mouse retinal RNAs this cDNA hybridized the cGMP-PDEγ mRNA which is 900 bp long. The mouse γ-subunit contains 87 amino acid residues which share 97.7% homology with the bovine polypeptide [(1986) FEBS Lett. 204, 288–292]. Only two amino acids have been changed, Ala 8 to Gly and Met 17 to Ile

Publisher: Published by Elsevier B.V.
Year: 1988
DOI identifier: 10.1016/0014-5793(88)80413-7
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