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Schistosoma mansoni Tegument Protein Sm29 Is Able to Induce a Th1-Type of Immune Response and Protection against Parasite Infection

By Fernanda C. Cardoso, Gilson C. Macedo, Elisandra Gava, Gregory T. Kitten, Vitor L. Mati, Alan L. de Melo, Marcelo V. Caliari, Giulliana T. Almeida, Thiago M. Venancio, Sergio Verjovski-Almeida and Sergio C. Oliveira

Abstract

Schistosomiasis is the most important human helminth infection in terms of morbidity and mortality. Although the efforts to develop a vaccine against this disease have experienced failures, a new generation of surface antigens revealed by proteomic studies changed this scenario. Our group has characterized the protein Sm29 described previously as one of the most exposed and expressed antigens in the outer tegument of Schistosoma mansoni. Studies in patients living in endemic areas for schistosomiasis revealed high levels of IgG1 and IgG3 anti-Sm29 in resistant individuals. In this study, confocal microscope analysis showed Sm29 present in the surface of lung-stage schistosoluma and adult worms. Recombinant Sm29, when used as vaccine candidate, induced high levels of protection in mice. This protection was associated with a typical Th1 immune response and reduction of worm burden, liver granulomas and in intestinal eggs. Further, microarray analysis of worms recovered from vaccinated mice showed significant down-regulation of several genes encoding previously characterized vaccine candidates and/or molecules exposed on the surface, suggesting an immune evasion strategy of schistosomes under immune attack. These results demonstrated that Sm29 as one of the important antigens with potential to compose a vaccine against schistosomiasis

Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:2553283
Provided by: PubMed Central

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Citations

  1. (2003). Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa.
  2. (2006). Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk.

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