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Type I interferon-dependent gene MxA in perinatal HIV-infected patients under antiretroviral therapy as marker for therapy failure and blood plasmacytoid dendritic cells depletion

By Raffaele Badolato, Claudia Ghidini, Fabio Facchetti, Federico Serana, Alessandra Sottini, Marco Chiarini, Elena Spinelli, Silvia Lonardi, Alessandro Plebani, Luigi Caimi and Luisa Imberti
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2002). Age-related changes in human blood dendritic cell subpopulations.
  2. (1998). Canal P: Pharmacokinetics of alphaIFN-2b in chronic hepatitis C virus patients undergoing chronic hemodialysis or with normal renal function: clinical implications.
  3. (2003). CC: Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals.
  4. (2008). CC: Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infection. J Acquir Immune Defic Syndr
  5. (1989). cDNA structures and regulation of two interferon-induced human Mx proteins. Mol Cell Biol
  6. (1985). Cesario T: Inactivation of interferon by serum and synovial fluids. Proc Soc Exp Biol Med
  7. (1990). Clinical pharmacokinetics of interferons. Clin Pharmacokinet
  8. (2000). CM: Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. J Gen Virol
  9. (2004). Cunningham CK: Newer treatments for HIV in children. Curr Opin Pediatr
  10. (1999). Death, destruction, danger and dendritic cells. Nat Med
  11. (1990). Deicher H: The human intracellular Mx-homologous protein is specifically induced by type I interferons.
  12. (1998). Dendritic cells and the control of immunity. Nature
  13. (1997). Dendritic cells: unique leukocyte populations which control the primary immune response. Blood
  14. (2002). DM: Increased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the Paediatric European Network for
  15. (2001). Fitzgerald-Bocarsly P: Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin Immunol
  16. (2006). FS: Differential restoration of myeloid and plasmacytoid dendritic cells in HIV-1-infected children after treatment with highly active antiretroviral therapy.
  17. (1998). Gallo RC: Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS. Proc Natl Acad Sci USA
  18. (2005). Genotyping for guiding drug choice in human immunodeficiency virus-infected children failing multiple antiretroviral treatment regimens. Pediatr Infect Dis J
  19. (2006). GM: Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients. Proc Natl Acad Sci USA
  20. (2006). GM: HIV-1 immunopathogenesis: How good interferon turns bad. Clin Immunol
  21. (2008). Hackstein H: Human monocytes represent a competitive source of interferon-alpha in peripheral blood. Clin Immunol
  22. (2001). Hosmalin A: Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection. Blood
  23. (2004). Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells.
  24. (2007). Imberti L: IFNbeta bioavailability in multiple sclerosis patients: MxA versus antibody-detecting assays.
  25. (2004). Imberti L: Reconstitution of T-cell compartment after in utero stem cell transplantation: analysis of T-cell repertoire and thymic output. Haematologica
  26. (1987). Interferon-alpha in sera of HIV-infected patients. Lancet
  27. (1991). Interferonalpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV-1 infection. AIDS Res Hum Retroviruses
  28. (1995). Interferons, Mx genes, and resistance to influenza virus.
  29. (2005). IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol
  30. (2006). L: Naive CD4(+) T cells and recent thymic emigrant levels in treated individuals with HIV: clinical relevance. AIDS Res Hum Retroviruses
  31. (2001). Liu YJ: Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood
  32. (2008). Loss of blood CD11c(+) myeloid and CD11c(-) plas-Journal of Translational Medicine
  33. (2007). MM: Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood
  34. (2005). Montaner LJ: Dendritic and natural killer cell subsets associated with stable or declining CD4+ cell counts in treated HIV-1-infected children. J Infect Dis
  35. (2002). Montaner LJ: Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals.
  36. (2003). MxA gene expression analysis as an interferon-beta bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity. Mol Diagn
  37. (2005). Orfao A: Different subsets of peripheral blood dendritic cells show distinct phenotypic and functional abnormalities in HIV-1 infection. AIDS
  38. (2004). PENTA Steering Committee: PENTA guidelines for the use of antiretroviral therapy,
  39. (2005). Plasmacytoid dendritic cells – virus experts of innate immunity. Semin Immunol
  40. (2005). Plasmacytoid dendritic cells: linking innate and adaptive immunity.
  41. (2003). R: Functional defects of dendritic cells in patients with CD40 deficiency. Blood
  42. (2006). T cell homeostasis in steady state and lymphopenic conditions. Immunol Lett
  43. (2004). The distribution of peripheral blood dendritic cells assayed by a new panel of antiBDCA monoclonal antibodies in healthy representatives of the polish population. Cell Mol Biol Lett
  44. (2004). Uittenbogaart CH: Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection.
  45. (2001). W i n k e l s G , Y a m a m o t o T , Z y s k M , Y a m a g u c h i Y , S c h m i t z J : BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.
  46. (1998). Wattré P: The MxA protein levels in whole blood lysates of patients with various viral infections.
  47. (1994). Wussow P: Strong transient expression of the type I interferon-induced MxA protein in hepatitis A but not in acute hepatitis B and C. Hepatology
  48. (2004). YJ: Plasmacytoid dendritic cells in immunity. Nat Immunol
  49. (1999). YJ: The nature of the principal type 1 interferon-producing cells in human blood. Science

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