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Feminization and reduction of testicular weight in mouse sparganosis

By Hyun-Jong Yang

Abstract

After infection of male mice with the plerocercoids (spargana) of Spirometra mansoni, serum levels of estrogen and testicular weight were analyzed by enzyme-linked immunosorbent assay (ELISA) and weighing machine, respectively. The serum level of estrogen increased progressively in infected mice compared with normal controls, whereas the testicular weight of infected mice decreased significantly (P < 0.05). These results suggest that certain substances from spargana change the steroid hormone metabolisms in the host by unknown pathways, and chronic infection may contribute to change of the function of steroid hormone target organ, i.e., testis, in male mice

Topics: Brief Communication
Publisher: The Korean Society for Parasitology
OAI identifier: oai:pubmedcentral.nih.gov:2532630
Provided by: PubMed Central
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