The clinical management of febrile children continues to evolve, especially in the light of vaccines against Haemophilus influenzae type B and more recently, Streptococcus pneumoniae. These vaccines have decreased the risk of serious bacterial illness in most children, allowing for a more selective approach to investigation and empirical treatment. However, children younger than three months of age still require an aggressive approach to investigation and careful follow-up. Certain laboratory criteria can allow safe management of even young infants on an outpatient basis. The present article outlines an age-based approach to investigation and management of children with fever
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