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Creation of Three-dimensional Liver Tissue Models from Experimental Images for Systems Medicine

By Stefan Hoehme, Adrian Friebel, Seddik Hammad, Dirk Drasdo and Jan G. Hengstler

Abstract

PubMed-listedInternational audienceIn this chapter, we illustrate how three-dimensional liver tissue models can be created from experimental image modalities by utilizing a well-established processing chain of experiments, microscopic imaging, image processing, image analysis and model construction. We describe how key features of liver tissue architecture are quantified and translated into model parameterizations, and show how a systematic iteration of experiments and model simulations often leads to a better understanding of biological phenomena in systems biology and systems medicine

Topics: TiQuant software, Systems medicine, liver tissue model, hepatocyte transplantation, 2D/3D microscopy, liver architecture, confocal scanning microscopy, [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [ SDV.MHEP.AHA ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [ SDV.MHEP.HEG ] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing
Publisher: Springer
Year: 2016
DOI identifier: 10.1007/978-1-4939-6506-9_22
OAI identifier: oai:HAL:hal-01426722v1
Provided by: Hal-Diderot
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