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G-Quadruplexes in DNA Replication: A Problem or a Necessity?

By Anne-Laure Valton and Marie-Noëlle Prioleau

Abstract

International audienceDNA replication is a highly regulated process that ensures the correct duplication of the genome at each cell cycle. A precise cell type-specific temporal program controls the duplication of complex vertebrate genomes in an orderly manner. This program is based on the regulation of both replication origin firing and replication fork progression. G-quadruplexes (G4s), DNA secondary structures displaying noncanonical Watson-Crick base pairing, have recently emerged as key controllers of genome duplication. Here we discuss the various means by which G4s affect this fundamental cellular process

Topics: DNA replication, G-quadruplex, genetic and epigenetic instability, helicase, replication origin, specialized polymerase, [ SDV.GEN ] Life Sciences [q-bio]/Genetics
Publisher: Elsevier
Year: 2016
DOI identifier: 10.1016/j.tig.2016.09.004
OAI identifier: oai:HAL:hal-01472913v1
Provided by: Hal-Diderot
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