Skip to main content
Article thumbnail
Location of Repository

Activation of mitotic kinesin by microtubule bundling

By Michio Tomishige

Abstract

Kinesin-5 family members cross-link and slide parallel microtubules of opposite polarity, an activity that is essential for the formation of a bipolar spindle during mitosis. In this issue, Kapitein et al. (Kapitein, L.C., B.H. Kwok, J.S. Weinger, C.F. Schmidt, T.M. Kapoor, and E.J.G. Peterman. 2008. J. Cell Biol. 182:421–428) demonstrate that microtubule cross-linking triggers the conversion of kinesin-5 motility from a diffusive mode to a directional mode, initiating antiparallel microtubule sliding

Topics: Reviews
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:2500127
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (1996). A bipolar kinesin.
    2. (2006). A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays.
    3. (2006). Allosteric inhibition of kinesin-5 modulates its processive directional motility.
    4. (2008). CENP-E combines a slow, processive motor and a fl exible coiled coil to produce an essential motile kinetochore tether.
    5. (2002). Conversion of Unc104/ KIF1A kinesin into a processive motor after dimerization.
    6. (2001). Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
    7. (2008). Getting in sync with dimeric Eg5: initiation and regulation of the processive run.
    8. (2006). Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro.
    9. (2007). Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells.
    10. (2007). Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.
    11. (2000). Mechanism of the single-headed processivity: diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin.
    12. (2008). Microtubule cross-linking triggers the directional motility of kinesin-5 .
    13. (2002). N é d é lec
    14. (2006). The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends.
    15. (2008). The kinesin-1 motor protein is regulated by a direct interaction of its head and tail.
    16. (2008). These new results by Kapitein

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.