Location of Repository

Association between SCN1A polymorphism and carbamazepine-resistant epilepsy

By Tomohide Abe, Takayuki Seo, Takateru Ishitsu, Takehiro Nakagawa, Masaharu Hori and Kazuko Nakagawa

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECTThe SCN1Agene encodes the α subunit of the neuronal voltage-gated sodium channel, which is a target for carbamazepine and other antiepileptic drugs (AEDs).Recent studies have demonstrated that a common polymorphism of SCN1A IVS5-91 G > A was associated with carbamazepine and phenytoin use in daily practice.However, it has not been determined whether the polymorphism affects carbamazepine or other AED responsiveness.WHAT THIS STUDY ADDSThis study demonstrated a significant association between the SCN1A IVS5-91 AA genotype and carbamazepine-resistant epilepsy, while the AA genotype did not affect carbamazepine use

Topics: Short Reports
Publisher: Blackwell Science Inc
OAI identifier: oai:pubmedcentral.nih.gov:2492927
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.