Skip to main content
Article thumbnail
Location of Repository

Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency

By Simon T. MacDonald, Simon D. Bamforth, Chiann-Mun Chen, Cassandra R. Farthing, Angela Franklyn, Carol Broadbent, Jürgen E. Schneider, Yumiko Saga, Mark Lewandoski and Shoumo Bhattacharya
Topics: Original Articles
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:2492730
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. A complex syndrome of left-right axis, central nervous system and axial skeleton defects
    2. (1999). A role of the cryptic gene in the correct establishment of the left-right axis.
    3. (2003). Cardiac chamber formation: development, genes, and evolution. Physiol Rev
    4. Cardiac malformations, adrenal agenesis, neural crest defects exencephaly in mice lacking
    5. (2003). Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development
    6. CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle.
    7. Cited2 controls left-right patterning and heart development through a Nodal!Pitx2c pathway.
    8. Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development.
    9. (1999). Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev
    10. (2006). Data analysis and reporting.
    11. (1999). Dosage requirement of Pitx2 for development of multiple organs.
    12. Ebner A et al. Identification and functional analysis of CITED2 mutations in patients with congenital heart defects.
    13. (2002). Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev
    14. Establishment of vertebrate left-right asymmetry.
    15. (2003). Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis.
    16. Fate of the mammalian cardiac neural crest.
    17. (2000). Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development
    18. (1999). Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev
    19. (2001). Identifi-cation and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects.
    20. Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique.
    21. Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferatoractivated receptor alpha coregulator.
    22. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development.
    23. (2003). Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell
    24. Left-right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left-right axis determination.
    25. Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.
    26. Maternal inheritance of Cre activity in a Sox2Cre deleter strain.
    27. (2000). Mesp1 expression is theearliestsign of cardiovascular development. Trends Cardiovasc Med
    28. (1999). MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development
    29. (1998). Modifi-cation of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase.
    30. (1999). MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alphasubunit gene expression.
    31. (1998). Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev
    32. (1999). Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways.
    33. NKX2.5 mutations in patients with congenital heart disease.
    34. (2001). NKX2.5 mutations in patients with tetralogy of fallot. Circulation
    35. Phenotyping transgenic embryos: a rapid 3-D screening method based on episcopic fluorescence image capturing.
    36. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.
    37. (2006). Quantitative analysis of ocular gene expression.
    38. (2001). Regulation of left-right asymmetry by thresholds of Pitx2c activity.
    39. (2005). Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development.
    40. (1999). The Anatomical Basis of Mouse Development.
    41. The essential role of Cited2, a negative regulator for HIF-1falphag, in heart development and neurulation.
    42. (1992). Whole mount in situ hybridization of vertebrate embryos.
    43. (1997). X-linked situs abnormalities result from mutations in ZIC3.
    44. (2000). X-linked transposition of the great arteries and incomplete penetrance among males with a nonsense mutation in ZIC3.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.