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Synthesis of new triazole-based trifluoromethyl scaffolds

By Michela Martinelli, Thierry Milcent, Sandrine Ongeri and Benoit Crousse


Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus offers an entry to new trifluoromethyl peptidomimetics as interesting scaffolds

Topics: Preliminary Communication
Publisher: Beilstein-Institut
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Provided by: PubMed Central
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