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The second chance story of HIV-1 DNA: Unintegrated? Not a problem!

By Yuntao Wu


Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector

Topics: Commentary
Publisher: BioMed Central
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