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Surfactant replacement and open lung concept – Comparison of two treatment strategies in an experimental model of neonatal ARDS

By Anne Hilgendorff, Ece Aslan, Thomas Schaible, Ludwig Gortner, Thorsten Baehner, Michael Ebsen, Jochen Kreuder, Clemens Ruppert, Andreas Guenther and Irwin Reiss
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2001). A: Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia. Am J Respir Crit Care Med
  2. (2002). A: An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid. Am J Respir Crit Care Med
  3. (2004). A: Increase in alveolar antioxidant levels in hyperoxic and anoxic ventilated rabbit lungs during ischemia. Free Radic Biol Med
  4. (1970). A: Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids
  5. (2001). B: Resistance of different surfactant preparations to inactivation by meconium. Pediatr Res
  6. (2004). B: Year in review in intensive care medicine,
  7. (1994). Bovine surfactant in full-term neonates with adult respiratory distress syndrome-like disorders. Pediatrics
  8. (2006). Cavigioli F: Bronchoalveolar lavage with diluted porcine surfactant in mechanically ventilated term infants with meconium aspiration syndrome. Clin Drug Investig
  9. (1990). E: Effects of bovine surfacant in premature lambs after intratracheal application.
  10. (2006). E: Protein- and lipid modification of natural bovine surfactant. Effects in experimental lung failure with special consideration of the response in neonates. Arzneimittelforschung
  11. (2004). Effect of pulmonary surfactant on TNF-alpha-activated endothelial cells and neutrophil adhesion in vitro. Immunobiology
  12. (2004). Effect of recombinant surfactant protein Cbased surfactant on the acute respiratory distress syndrome.
  13. (1999). Effects of early treatment with rSP-C surfactant on oxygenation and histology in rats with acute lung injury. Pulm Pharmacol Ther
  14. (2005). Egan EA: Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial. Jama
  15. (1995). ELISA technique for quantification of surfactant protein B (SP-B) in bronchoalveolar lavage fluid.
  16. (1997). Exogenous surfactant and partial liquid ventilation: physiologic and pathologic effects.
  17. (1996). FJ: Surfactant replacement therapy for meconium aspiration syndrome. Pediatrics
  18. (2003). Gortner L: Treatment with bovine surfactant in severe acute respiratory distress syndrome in children: a randomized multicenter study. Intensive Care Med
  19. (1980). In vivo lung lavage as an experimental model of the respiratory distress syndrome. Acta Anaesthesiol Scand
  20. (1998). JH: Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. Survanta in Term Infants Study Group. J Pediatr
  21. (2003). Lachmann B: Application of the open-lung concept during positive-pressure ventilation reduces pulmonary inflammation in newborn piglets. Biol Neonate
  22. (2003). Lachmann B: Positive pressure ventilation with the open lung concept optimizes gas exchange and reduces ventilatorinduced lung injury in newborn piglets. Pediatr Res
  23. (2004). Lachmann B: Response to exogenous surfactant is different during open lung and conventional ventilation. Crit Care Med
  24. (1998). Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant. Am J Respir Crit Care Med
  25. (2001). Membrane activity of (Cys48Ser) lung surfactant protein B increases with dimerisation. Biol Chem
  26. (2006). Open lung ventilation preserves the response to delayed surfactant treatment in surfactant-deficient newborn piglets. Crit Care Med
  27. (1999). PG: A rat model of acute respiratory distress syndrome (ARDS) Part 2, influence of lavage volume, lavage repetition, and therapeutic treatment with rSP-C surfactant.
  28. (2006). Reiss I: Effects of a recombinant surfactant protein-C-based surfactant on lung function and the pulmonary surfactant system in a model of meconium aspiration syndrome. Crit Care Med
  29. (2003). Reiss I: Synthetic and natural surfactant differentially modulate inflammation after meconium aspiration. Intensive Care Med
  30. (2006). Rimensberger PC: Lung volume recruitment after surfactant administration modifies spatial distribution of ventilation.
  31. (2007). Rimensberger PC: Lung-protective ventilation strategies in neonatology: what do we know--what do we need to know? Crit Care Med
  32. (1991). Shapiro DL: Surfactant treatment of full-term newborns with respiratory failure. Pediatrics
  33. (2002). Surfactant improves oxygenation in infants and children with pneumonia and acute respiratory distress syndrome. Acta Paediatr
  34. (2000). TE: The role of homodimers in surfactant protein B function in vivo.
  35. (2006). Traber DL: Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis. Crit Care Med
  36. (1996). W: Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Am J Respir Crit Care Med
  37. (1959). WJ: A rapid method of total lipid extraction and purification.
  38. (2005). Year in review in intensive care medicine.

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