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Alzheimer's disease and HIV associated dementia related genes: I. location and function

By Paul Shapshak, Hector E Rodriguez, Rajarathinam Kayathri, Andrew Levine, Francesco Chiappelli and Alireza Minagar


Alzheimer's disease (AD), the most common cause of dementia, has few clinical similarities to HIV-1-associated dementia (HAD). However, genes were identified related among these dementias. Discovering correlations between gene function, expression, and structure in the human genome continues to aid in understanding the similarities between pathogenesis of these two dementing disorders. The current work attempts to identify relationships between these dementias in spite of their clinical differences, based on genomic structure, function, and expression. In this comparative study, the NCBI Entrez Genome Database is used to detect these relationships. This approach serves as a model for future diagnosis and treatment in the clinical arena as well as suggesting parallel pathways of disease mechanisms. Identifying a correlation among expression, structure, and function of genes involved in pathogenesis of these dementing disorders, may assist to understand better their interaction with each other and the human genome

Topics: Hypothesis
Publisher: Biomedical Informatics Publishing Group
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Provided by: PubMed Central
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