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Leptin in Children with Newly Diagnosed Type 1 Diabetes: Effect of Insulin Therapy

By Kenneth L. McCormick, Gail J. Mick, Lisa Butterfield, Hugh Ross, Elaine Parton and Joan Totka


Leptin, the gene product of adipose tissue that signals caloric plentitude via central nervous system receptors, may also have diverse peripheral metabolic actions. Of paramount interest has been the potential interaction(s) between leptin and insulin. Insofar as insulin alters leptin secretion/action (or vice versa), dysregulation of this system could contribute to disease states such as diabetes

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Publisher: Hindawi Publishing Corporation
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