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Colonic and colorectal cancer stem cells: progress in the search for putative biomarkers

By Naomi D Willis, Stefan A Przyborski, Christopher J Hutchison and Robert G Wilson

Abstract

The maintenance of healthy colonic crypts is dependent on the integrity of the adult epithelial stem cells located within them. Perturbations in stem cell dynamics are generally believed to represent the first step towards colorectal tumorigenesis. Experimental manipulation of intestinal stem cells has greatly increased our understanding of them, but further progress has been slowed due to the absence of a reliable stem cell biomarker. In this review we discuss the candidate colonic stem cell biomarkers which have been proposed. Furthermore, we investigate the putative biomarkers for so-called colorectal cancer stem cells, a highly aggressive subpopulation of cells considered to drive tumour development

Topics: Reviews
Publisher: Blackwell Science Inc
OAI identifier: oai:pubmedcentral.nih.gov:2475556
Provided by: PubMed Central
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