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Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus

By Jean-François Rossignol

Abstract

SummaryNitazoxanide is a broad-spectrum antiviral agent undergoing clinical development for treatment of influenza and other viral respiratory infections. Nitazoxanide exhibits in vitro activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and other coronaviruses, inhibiting expression of the viral N protein. Nitazoxanide also suppresses production of pro-inflammatory cytokines in peripheral blood mononuclear cells and suppresses interleukin 6 production in mice. Having been used extensively in clinical trials and in post-marketing experience, nitazoxanide is an attractive drug candidate for treatment of Middle East respiratory syndrome. Future research should include in vitro mechanism studies, animal models of MERS-CoV infection, clinical trials, including dose-ranging trials, and evaluation of combination therapy with other potential MERS-CoV antivirals

Publisher: King Saud Bin Abdulaziz University for Health Sciences. Production and hosting by Elsevier Limited.
Year: 2016
DOI identifier: 10.1016/j.jiph.2016.04.001
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