Skip to main content
Article thumbnail
Location of Repository

Squalamine: An Appropriate Strategy against the Emergence of Multidrug Resistant Gram-Negative Bacteria?

By Chanaz Salmi, Celine Loncle, Nicolas Vidal, Yves Letourneux, Jacques Fantini, Marc Maresca, Nadira Taïeb, Jean-Marie Pagès and Jean Michel Brunel

Abstract

We reported that squalamine is a membrane-active molecule that targets the membrane integrity as demonstrated by the ATP release and dye entry. In this context, its activity may depend on the membrane lipid composition. This molecule shows a preserved activity against bacterial pathogens presenting a noticeable multi-resistance phenotype against antibiotics such as polymyxin B. In this context and because of its structure, action and its relative insensitivity to efflux resistance mechanisms, we have demonstrated that squalamine appears as an alternate way to combat MDR pathogens and by pass the gap regarding the failure of new active antibacterial molecules

Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:2447875
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (1992). Agents that increase the permeability of the outer membrane.
    2. (1994). Antibacterial molecules from frogs, sharks and man. Phylogenet Perspect Immun Insect Host Def.
    3. (1992). Antibiotic peptides as mediators of innate immunity.
    4. (2002). Antimicrobial peptides of multicellular organisms.
    5. (2002). High affinity binding of long-chain polysialic acid to antibody, and modulation by divalent cations and polyamines.
    6. (1985). High state of order of isolated bacterial lipopolysaccharide and its possible contribution to the permeation barrier property of the outer membrane.
    7. (2005). Lysinespermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants.
    8. (2003). Molecular basis of bacterial outer membrane permeability revisited.
    9. (1994). Multiple-antibiotic-resistant pathogenic bacteria. A report on the Rockefeller University workshop.
    10. (1993). Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in gram-negative enteric bacteria.
    11. (1996). Outer membrane. In:
    12. (2007). PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium.
    13. (2001). Surveillance of antimicrobial resistance-xhat, how and whither?
    14. (1997). The bacterial outer membrane as a drug barrier.
    15. (1995). Tomasz A

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.