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Enhancement of Diagnostic Efficiency by a Gamma Interferon Release Assay for Pulmonary Tuberculosis▿

By Kelly Aparecida Kanunfre, Olavo Henrique Munhoz Leite, Max Igor Lopes, Marcelo Litvoc and Antonio Walter Ferreira


This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to ≥0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test

Topics: Clinical Laboratory Immunology
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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